Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine

Asma Agrebi; Fatma Allouche; Fakher Chabchoub; Laurent El-Kaim; Sérgio Alves; Carlos Baleizão; José Paulo Farinha

doi:10.1016/j.tetlet.2013.06.136

Sc(OTf)₃ promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine

Asma Agrebi
, Fatma Allouche
, Fakher Chabchoub
, Laurent El-Kaim
, Sérgio Alves
, Carlos Baleizão
, José Paulo Farinha

Research output: Contribution to journal › Article › peer-review

Abstract

A three-component condensation reaction between aminopyrazolo[3,4-d] pyrimidine, an aldehyde, and an isocyanide catalyzed by scandium triflate yields a series of heterocyclic derivatives of imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine in good yields, exhibiting interesting fluorescent properties.

Original language	English
Pages (from-to)	4781-4784
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	35
DOIs	https://doi.org/10.1016/j.tetlet.2013.06.136
Publication status	Published - 28 Aug 2013
Externally published	Yes

Keywords

Fluorescent probes
Imidazo[12-c]pyrazolo[3,4-d]pyrimidine
Multicomponent reactions (MCRs)
Pyrazolopyrimidine
Scandium triflate

Access to Document

10.1016/j.tetlet.2013.06.136

Cite this

@article{47eb44a4cd614153b6aeef3ca2af8b2f,

title = "Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine",

abstract = "A three-component condensation reaction between aminopyrazolo[3,4-d] pyrimidine, an aldehyde, and an isocyanide catalyzed by scandium triflate yields a series of heterocyclic derivatives of imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine in good yields, exhibiting interesting fluorescent properties.",

keywords = "Fluorescent probes, Imidazo[12-c]pyrazolo[3,4-d]pyrimidine, Multicomponent reactions (MCRs), Pyrazolopyrimidine, Scandium triflate",

author = "Asma Agrebi and Fatma Allouche and Fakher Chabchoub and Laurent El-Kaim and S{\'e}rgio Alves and Carlos Baleiz{\~a}o and Farinha, \{Jos{\'e} Paulo\}",

year = "2013",

month = aug,

day = "28",

doi = "10.1016/j.tetlet.2013.06.136",

language = "English",

volume = "54",

pages = "4781--4784",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "35",

}

TY - JOUR

T1 - Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine

AU - Agrebi, Asma

AU - Allouche, Fatma

AU - Chabchoub, Fakher

AU - El-Kaim, Laurent

AU - Alves, Sérgio

AU - Baleizão, Carlos

AU - Farinha, José Paulo

PY - 2013/8/28

Y1 - 2013/8/28

N2 - A three-component condensation reaction between aminopyrazolo[3,4-d] pyrimidine, an aldehyde, and an isocyanide catalyzed by scandium triflate yields a series of heterocyclic derivatives of imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine in good yields, exhibiting interesting fluorescent properties.

AB - A three-component condensation reaction between aminopyrazolo[3,4-d] pyrimidine, an aldehyde, and an isocyanide catalyzed by scandium triflate yields a series of heterocyclic derivatives of imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine in good yields, exhibiting interesting fluorescent properties.

KW - Fluorescent probes

KW - Imidazo[12-c]pyrazolo[3,4-d]pyrimidine

KW - Multicomponent reactions (MCRs)

KW - Pyrazolopyrimidine

KW - Scandium triflate

U2 - 10.1016/j.tetlet.2013.06.136

DO - 10.1016/j.tetlet.2013.06.136

M3 - Article

AN - SCOPUS:84880824316

SN - 0040-4039

VL - 54

SP - 4781

EP - 4784

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35