TY - JOUR
T1 - Selective Tsuji-Trost type C-allylation of hydrazones
T2 - a straightforward entry into 4,5-dihydropyrazoles
AU - El Mamouni, El Hachemia
AU - Cattoen, Martin
AU - Cordier, Marie
AU - Cossy, Janine
AU - Arseniyadis, Stellios
AU - Ilitki, Hocine
AU - El Kaïm, Laurent
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
AB - The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
U2 - 10.1039/c6cc08171a
DO - 10.1039/c6cc08171a
M3 - Article
AN - SCOPUS:85006305843
SN - 1359-7345
VL - 52
SP - 14490
EP - 14493
JO - Chemical Communications
JF - Chemical Communications
IS - 100
ER -