@inproceedings{8e9c0ed6e66440909c26af509e16ae38,
title = "Sickling red blood cells in droplet arrays",
abstract = "By micro fabricating holes into a grid pattern on the channel top surface, drops can be arrayed and held in place against the mean carrier oil flow. The oxygen content of the anchored drops is modulated by gas exchange with the flowing carrier oil. Oxygen control is used to selectively deoxygenate droplets that encapsulate red blood cells from patients suffering from sickle cell disease, in order to study the polymerization of intracellular hemoglobin. Cycles of oxygenation and deoxygenation of anchored droplets induce depolymerization and polymerization of the hemoglobin that is detected by polarization microscopy, thus providing a method to simulate the cycling that takes place in physiological flows.",
keywords = "Droplet microfluidics, Oxygen, Red blood cells, Sickle cell disease",
author = "P. Abbyad and R. Dangla and Tharaux, \{P. L.\} and A. Alexandrou and Baroud, \{C. N.\}",
year = "2010",
month = dec,
day = "1",
language = "English",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "2047--2049",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}