Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction

Oscar Mendoza; Juan Elezgaray; Jean Louis Mergny

doi:10.1016/j.dib.2015.10.039

Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction

Oscar Mendoza
, Juan Elezgaray
, Jean Louis Mergny

Research output: Contribution to journal › Article › peer-review

Abstract

This article describes additional data related to a research article entitled "Kinetics of Quadruplex to Duplex Conversion" (Mendoza et al. 2015 [1]). We followed the opening reaction of a series of intramolecular G-quadruplex structures by the addition of their corresponding complementary strand. Fluorolabeled complementary strands allowed to monitor the reaction in real-time. An adapted kinetic model was then applied in order to obtain the kinetic parameters of this reaction.We present a series of kinetic traces providing raw data of the G4 opening reaction and the fitting model applied in every case. In addition CD spectra and UV melting data is also provided to confirm the stability of all the DNA structures considered (G-quadruplex and duplex DNA).

Original language	English
Pages (from-to)	822-828
Number of pages	7
Journal	Data in Brief
Volume	5
DOIs	https://doi.org/10.1016/j.dib.2015.10.039
Publication status	Published - 1 Dec 2015
Externally published	Yes

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10.1016/j.dib.2015.10.039

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title = "Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction",

abstract = "This article describes additional data related to a research article entitled {"}Kinetics of Quadruplex to Duplex Conversion{"} (Mendoza et al. 2015 [1]). We followed the opening reaction of a series of intramolecular G-quadruplex structures by the addition of their corresponding complementary strand. Fluorolabeled complementary strands allowed to monitor the reaction in real-time. An adapted kinetic model was then applied in order to obtain the kinetic parameters of this reaction.We present a series of kinetic traces providing raw data of the G4 opening reaction and the fitting model applied in every case. In addition CD spectra and UV melting data is also provided to confirm the stability of all the DNA structures considered (G-quadruplex and duplex DNA).",

author = "Oscar Mendoza and Juan Elezgaray and Mergny, \{Jean Louis\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = dec,

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doi = "10.1016/j.dib.2015.10.039",

language = "English",

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journal = "Data in Brief",

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T1 - Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction

AU - Mendoza, Oscar

AU - Elezgaray, Juan

AU - Mergny, Jean Louis

PY - 2015/12/1

Y1 - 2015/12/1

N2 - This article describes additional data related to a research article entitled "Kinetics of Quadruplex to Duplex Conversion" (Mendoza et al. 2015 [1]). We followed the opening reaction of a series of intramolecular G-quadruplex structures by the addition of their corresponding complementary strand. Fluorolabeled complementary strands allowed to monitor the reaction in real-time. An adapted kinetic model was then applied in order to obtain the kinetic parameters of this reaction.We present a series of kinetic traces providing raw data of the G4 opening reaction and the fitting model applied in every case. In addition CD spectra and UV melting data is also provided to confirm the stability of all the DNA structures considered (G-quadruplex and duplex DNA).

AB - This article describes additional data related to a research article entitled "Kinetics of Quadruplex to Duplex Conversion" (Mendoza et al. 2015 [1]). We followed the opening reaction of a series of intramolecular G-quadruplex structures by the addition of their corresponding complementary strand. Fluorolabeled complementary strands allowed to monitor the reaction in real-time. An adapted kinetic model was then applied in order to obtain the kinetic parameters of this reaction.We present a series of kinetic traces providing raw data of the G4 opening reaction and the fitting model applied in every case. In addition CD spectra and UV melting data is also provided to confirm the stability of all the DNA structures considered (G-quadruplex and duplex DNA).

UR - https://www.scopus.com/pages/publications/84947052900

U2 - 10.1016/j.dib.2015.10.039

DO - 10.1016/j.dib.2015.10.039

M3 - Article

AN - SCOPUS:84947052900

SN - 2352-3409

VL - 5

SP - 822

EP - 828

JO - Data in Brief

JF - Data in Brief

ER -

Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction

Abstract

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