Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments

Rhoda J. Hawkins; Renaud Poincloux; Olivier Bénichou; Matthieu Piel; Philippe Chavrier; Raphaël Voituriez

doi:10.1016/j.bpj.2011.07.038

Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments

Rhoda J. Hawkins
, Renaud Poincloux
, Olivier Bénichou
, Matthieu Piel
, Philippe Chavrier
, Raphaël Voituriez

Université Pierre et Marie Curie
Centre national de la recherche scientifique
Department of Mathematics
University of Bristol

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.

Original language	English
Pages (from-to)	1041-1045
Number of pages	5
Journal	Biophysical Journal
Volume	101
Issue number	5
DOIs	https://doi.org/10.1016/j.bpj.2011.07.038
Publication status	Published - 7 Sept 2011
Externally published	Yes

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abstract = "We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.",

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AU - Hawkins, Rhoda J.

AU - Poincloux, Renaud

AU - Bénichou, Olivier

AU - Piel, Matthieu

AU - Chavrier, Philippe

AU - Voituriez, Raphaël

PY - 2011/9/7

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N2 - We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.

AB - We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.

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DO - 10.1016/j.bpj.2011.07.038

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JO - Biophysical Journal

JF - Biophysical Journal

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Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments

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