Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Emmanuel Cazottes; Claire Rougeulle

doi:10.1016/j.stem.2020.08.008

Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Emmanuel Cazottes
, Claire Rougeulle

Laboratoire de Probabilités et Modèles Aléatoires

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

Original language	English
Pages (from-to)	352-353
Number of pages	2
Journal	Cell Stem Cell
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2020.08.008
Publication status	Published - 3 Sept 2020
Externally published	Yes

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10.1016/j.stem.2020.08.008

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title = "Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade",

abstract = "In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.",

author = "Emmanuel Cazottes and Claire Rougeulle",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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T2 - Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

AU - Cazottes, Emmanuel

AU - Rougeulle, Claire

PY - 2020/9/3

Y1 - 2020/9/3

N2 - In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

AB - In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

UR - https://www.scopus.com/pages/publications/85089957041

U2 - 10.1016/j.stem.2020.08.008

DO - 10.1016/j.stem.2020.08.008

M3 - Comment/debate

C2 - 32888422

AN - SCOPUS:85089957041

SN - 1934-5909

VL - 27

SP - 352

EP - 353

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 3

ER -

Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

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