Studies towards the synthesis of Fipronil® analogues: Improved decarboxylation of α-hydrazonoacid derivatives

J. E. Ancel; L. El Kaïm; A. Gadras; L. Grimaud; N. K. Jana

doi:10.1016/S0040-4039(02)01977-9

Studies towards the synthesis of Fipronil® analogues: Improved decarboxylation of α-hydrazonoacid derivatives

J. E. Ancel
, L. El Kaïm
, A. Gadras
, L. Grimaud
, N. K. Jana

Centre de Recherche de Vitry-Alfortville
Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil®. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation.

Original language	English
Pages (from-to)	8319-8321
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(02)01977-9
Publication status	Published - 11 Nov 2002
Externally published	Yes

Access to Document

10.1016/S0040-4039(02)01977-9

Cite this

@article{297cf72c2d44416994df27a271ba9137,

title = "Studies towards the synthesis of Fipronil{\textregistered} analogues: Improved decarboxylation of α-hydrazonoacid derivatives",

abstract = "The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil{\textregistered}. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation.",

author = "Ancel, \{J. E.\} and \{El Ka{\"i}m\}, L. and A. Gadras and L. Grimaud and Jana, \{N. K.\}",

year = "2002",

month = nov,

day = "11",

doi = "10.1016/S0040-4039(02)01977-9",

language = "English",

volume = "43",

pages = "8319--8321",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "46",

}

TY - JOUR

T1 - Studies towards the synthesis of Fipronil® analogues

T2 - Improved decarboxylation of α-hydrazonoacid derivatives

AU - Ancel, J. E.

AU - El Kaïm, L.

AU - Gadras, A.

AU - Grimaud, L.

AU - Jana, N. K.

PY - 2002/11/11

Y1 - 2002/11/11

N2 - The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil®. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation.

AB - The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil®. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation.

U2 - 10.1016/S0040-4039(02)01977-9

DO - 10.1016/S0040-4039(02)01977-9

M3 - Article

AN - SCOPUS:0037064491

SN - 0040-4039

VL - 43

SP - 8319

EP - 8321

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Studies towards the synthesis of Fipronil® analogues: Improved decarboxylation of α-hydrazonoacid derivatives

Abstract

Access to Document

Fingerprint

Cite this