Suck-Back Impact on Fluid Behavior at Filling Needle Tip

Maria Clara Novaes Silva; Jean René Authelin; David Quéré; Charlotte Pellet

doi:10.1016/j.xphs.2019.11.005

Suck-Back Impact on Fluid Behavior at Filling Needle Tip

Maria Clara Novaes Silva
, Jean René Authelin
, David Quéré
, Charlotte Pellet

Centre de Recherche de Vitry-Alfortville
PSL Research University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Needle clogging induces several issues during the filling step of injectable drugs, which makes essential to avoiding it to ensure a favorable outcome for the process. The suck-back function, present in peristaltic pumps, is often used empirically to that end. This study aims at describing and understanding the fluid behavior after suck-back application, which provides some quantitative specifications to prevent needle clogging.

Original language	English
Pages (from-to)	1123-1129
Number of pages	7
Journal	Journal of Pharmaceutical Sciences
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.xphs.2019.11.005
Publication status	Published - 1 Feb 2020
Externally published	Yes

Keywords

drying
filling
injectable(s)
monoclonal antibody(s)
physicochemical
processing
protein formulation(s)
surfactant(s)
viscosity
wetting

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10.1016/j.xphs.2019.11.005

Cite this

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title = "Suck-Back Impact on Fluid Behavior at Filling Needle Tip",

abstract = "Needle clogging induces several issues during the filling step of injectable drugs, which makes essential to avoiding it to ensure a favorable outcome for the process. The suck-back function, present in peristaltic pumps, is often used empirically to that end. This study aims at describing and understanding the fluid behavior after suck-back application, which provides some quantitative specifications to prevent needle clogging.",

keywords = "drying, filling, injectable(s), monoclonal antibody(s), physicochemical, processing, protein formulation(s), surfactant(s), viscosity, wetting",

author = "\{Novaes Silva\}, \{Maria Clara\} and Authelin, \{Jean Ren{\'e}\} and David Qu{\'e}r{\'e} and Charlotte Pellet",

note = "Publisher Copyright: {\textcopyright} 2020 American Pharmacists Association{\textregistered}",

year = "2020",

month = feb,

day = "1",

doi = "10.1016/j.xphs.2019.11.005",

language = "English",

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journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

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TY - JOUR

T1 - Suck-Back Impact on Fluid Behavior at Filling Needle Tip

AU - Novaes Silva, Maria Clara

AU - Authelin, Jean René

AU - Quéré, David

AU - Pellet, Charlotte

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Needle clogging induces several issues during the filling step of injectable drugs, which makes essential to avoiding it to ensure a favorable outcome for the process. The suck-back function, present in peristaltic pumps, is often used empirically to that end. This study aims at describing and understanding the fluid behavior after suck-back application, which provides some quantitative specifications to prevent needle clogging.

AB - Needle clogging induces several issues during the filling step of injectable drugs, which makes essential to avoiding it to ensure a favorable outcome for the process. The suck-back function, present in peristaltic pumps, is often used empirically to that end. This study aims at describing and understanding the fluid behavior after suck-back application, which provides some quantitative specifications to prevent needle clogging.

KW - drying

KW - filling

KW - injectable(s)

KW - monoclonal antibody(s)

KW - physicochemical

KW - processing

KW - protein formulation(s)

KW - surfactant(s)

KW - viscosity

KW - wetting

U2 - 10.1016/j.xphs.2019.11.005

DO - 10.1016/j.xphs.2019.11.005

M3 - Article

C2 - 31730778

AN - SCOPUS:85076456529

SN - 0022-3549

VL - 109

SP - 1123

EP - 1129

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 2

ER -

Suck-Back Impact on Fluid Behavior at Filling Needle Tip

Abstract

Keywords

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