Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

  • Zhen Liu
  • , Quynh P.H. Nguyen
  • , Rashmi Nanjundappa
  • , Nathalie Delgehyr
  • , Alexandre Megherbi
  • , Regan Doherty
  • , James Thompson
  • , Claire Jackson
  • , Alexandra Albulescu
  • , Yew M. Heng
  • , Jane S. Lucas
  • , Sharon D. Dell
  • , Alice Meunier
  • , Kirk Czymmek
  • , Moe R. Mahjoub
  • , Vito Mennella

Research output: Contribution to journalArticlepeer-review

Abstract

Liu, Nguyen et al. show that among hundreds of cilia of a multiciliated cell, there is one that differs from the others in structure, origin, and cellular position, and it participates in basal body alignment.

Original languageEnglish
Pages (from-to)224-236.e6
JournalDevelopmental Cell
Volume55
Issue number2
DOIs
Publication statusPublished - 26 Oct 2020

Keywords

  • FIB-SEM
  • airway
  • appendages
  • basal bodies
  • basal foot
  • centrosome
  • cilia
  • electron microscopy
  • primary ciliary dyskinesia
  • quantitative imaging
  • super-resolution imaging

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