Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Mathieu Sassatelli; Fadoua Bouchikhi; Samir Messaoudi; Fabrice Anizon; Eric Debiton; Chantal Barthomeuf; Michelle Prudhomme; Pascale Moreau

doi:10.1016/j.ejmech.2005.10.004

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Mathieu Sassatelli
, Fadoua Bouchikhi
, Samir Messaoudi
, Fabrice Anizon
, Eric Debiton
, Chantal Barthomeuf
, Michelle Prudhomme
, Pascale Moreau

Clermont-Auvergne University
Centre Jean Perrin

Research output: Contribution to journal › Article › peer-review

Abstract

In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

Original language	English
Pages (from-to)	88-100
Number of pages	13
Journal	European Journal of Medicinal Chemistry
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2005.10.004
Publication status	Published - 1 Jan 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiproliferative activities
Indigoids
Isoindigos

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10.1016/j.ejmech.2005.10.004

Cite this

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title = "Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives",

abstract = "In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.",

keywords = "Antiproliferative activities, Indigoids, Isoindigos",

author = "Mathieu Sassatelli and Fadoua Bouchikhi and Samir Messaoudi and Fabrice Anizon and Eric Debiton and Chantal Barthomeuf and Michelle Prudhomme and Pascale Moreau",

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doi = "10.1016/j.ejmech.2005.10.004",

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AU - Sassatelli, Mathieu

AU - Bouchikhi, Fadoua

AU - Messaoudi, Samir

AU - Anizon, Fabrice

AU - Debiton, Eric

AU - Barthomeuf, Chantal

AU - Prudhomme, Michelle

AU - Moreau, Pascale

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

AB - In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

KW - Antiproliferative activities

KW - Indigoids

KW - Isoindigos

U2 - 10.1016/j.ejmech.2005.10.004

DO - 10.1016/j.ejmech.2005.10.004

M3 - Article

C2 - 16330129

AN - SCOPUS:33244484119

SN - 0223-5234

VL - 41

SP - 88

EP - 100

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Abstract

UN SDGs

Keywords

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