Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process

Luis E. Cárdenas-Galindo; Alejandro Islas-Jácome; Nancy V. Alvarez-Rodríguez; Laurent El Kaim; Rocío Gámez-Montaño

doi:10.1055/s-0033-1340051

Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process

Luis E. Cárdenas-Galindo
, Alejandro Islas-Jácome
, Nancy V. Alvarez-Rodríguez
, Laurent El Kaim
, Rocío Gámez-Montaño

Research output: Contribution to journal › Article › peer-review

Abstract

A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β- carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems.

Original language	English
Article number	SS-2013-F0493-OP
Pages (from-to)	49-56
Number of pages	8
Journal	Synthesis
Volume	46
Issue number	1
DOIs	https://doi.org/10.1055/s-0033-1340051
Publication status	Published - 2 Jan 2014
Externally published	Yes

Keywords

MCR
Pictet-Spengler
Ugi-azide
tetrahydro-1 H -β-carbolines
tetrazoles

Access to Document

10.1055/s-0033-1340051

Cite this

@article{421370527ba0438e8fc7d73849591852,

title = "Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process",

abstract = "A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β- carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems.",

keywords = "MCR, Pictet-Spengler, Ugi-azide, tetrahydro-1 H -β-carbolines, tetrazoles",

author = "C{\'a}rdenas-Galindo, \{Luis E.\} and Alejandro Islas-J{\'a}come and Alvarez-Rodr{\'i}guez, \{Nancy V.\} and \{El Kaim\}, Laurent and Roc{\'i}o G{\'a}mez-Monta{\~n}o",

year = "2014",

month = jan,

day = "2",

doi = "10.1055/s-0033-1340051",

language = "English",

volume = "46",

pages = "49--56",

journal = "Synthesis",

issn = "0039-7881",

number = "1",

}

TY - JOUR

T1 - Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process

AU - Cárdenas-Galindo, Luis E.

AU - Islas-Jácome, Alejandro

AU - Alvarez-Rodríguez, Nancy V.

AU - El Kaim, Laurent

AU - Gámez-Montaño, Rocío

PY - 2014/1/2

Y1 - 2014/1/2

N2 - A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β- carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems.

AB - A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β- carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems.

KW - MCR

KW - Pictet-Spengler

KW - Ugi-azide

KW - tetrahydro-1 H -β-carbolines

KW - tetrazoles

UR - https://www.scopus.com/pages/publications/84890549952

U2 - 10.1055/s-0033-1340051

DO - 10.1055/s-0033-1340051

M3 - Article

AN - SCOPUS:84890549952

SN - 0039-7881

VL - 46

SP - 49

EP - 56

JO - Synthesis

JF - Synthesis

IS - 1

M1 - SS-2013-F0493-OP

ER -

Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this