Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

Gaëlle Le Bras; Abdallah Hamze; Samir Messaoudi; Olivier Provot; Pierre Benoît Le Calvez; Jean Daniel Brion; Mouâd Alami

doi:10.1055/s-2008-1072575

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

Gaëlle Le Bras
, Abdallah Hamze
, Samir Messaoudi
, Olivier Provot
, Pierre Benoît Le Calvez
, Jean Daniel Brion
, Mouâd Alami

Université Paris-Saclay

Research output: Contribution to journal › Article › peer-review

Abstract

p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

Original language	English
Article number	Z03208SS
Pages (from-to)	1607-1611
Number of pages	5
Journal	Synthesis
Issue number	10
DOIs	https://doi.org/10.1055/s-2008-1072575
Publication status	Published - 19 May 2008
Externally published	Yes

Keywords

Alkynes
Annulations
Isochromene
Isocoumarin
Microwave activation

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10.1055/s-2008-1072575

Cite this

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title = "Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes",

abstract = "p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.",

keywords = "Alkynes, Annulations, Isochromene, Isocoumarin, Microwave activation",

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T1 - Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

AU - Le Bras, Gaëlle

AU - Hamze, Abdallah

AU - Messaoudi, Samir

AU - Provot, Olivier

AU - Le Calvez, Pierre Benoît

AU - Brion, Jean Daniel

AU - Alami, Mouâd

PY - 2008/5/19

Y1 - 2008/5/19

N2 - p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

AB - p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.

KW - Alkynes

KW - Annulations

KW - Isochromene

KW - Isocoumarin

KW - Microwave activation

UR - https://www.scopus.com/pages/publications/44949100255

U2 - 10.1055/s-2008-1072575

DO - 10.1055/s-2008-1072575

M3 - Article

AN - SCOPUS:44949100255

SN - 0039-7881

SP - 1607

EP - 1611

JO - Synthesis

JF - Synthesis

IS - 10

M1 - Z03208SS

ER -

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

Abstract

Keywords

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