Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

Yeon Chun Yoo; Hak Yong Kim; Fan Long Jin; Soo Jin Park

doi:10.1007/s13233-013-1071-0

Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

Yeon Chun Yoo
, Hak Yong Kim
, Fan Long Jin
, Soo Jin Park

Research output: Contribution to journal › Article › peer-review

Abstract

A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by ¹H nuclear magnetic resonance (NMR) and ¹³C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.

Original language	English
Pages (from-to)	687-692
Number of pages	6
Journal	Macromolecular Research
Volume	21
Issue number	6
DOIs	https://doi.org/10.1007/s13233-013-1071-0
Publication status	Published - 1 Jun 2013
Externally published	Yes

Keywords

bioabsorbable
copolymer
monofilament
poly(glycolide caprolactone)
suture materials

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10.1007/s13233-013-1071-0

Cite this

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title = "Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials",

abstract = "A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR) and 13C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.",

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doi = "10.1007/s13233-013-1071-0",

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TY - JOUR

T1 - Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

AU - Yoo, Yeon Chun

AU - Kim, Hak Yong

AU - Jin, Fan Long

AU - Park, Soo Jin

PY - 2013/6/1

Y1 - 2013/6/1

N2 - A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR) and 13C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.

AB - A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR) and 13C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.

KW - bioabsorbable

KW - copolymer

KW - monofilament

KW - poly(glycolide caprolactone)

KW - suture materials

UR - https://www.scopus.com/pages/publications/84878010674

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DO - 10.1007/s13233-013-1071-0

M3 - Article

AN - SCOPUS:84878010674

SN - 1598-5032

VL - 21

SP - 687

EP - 692

JO - Macromolecular Research

JF - Macromolecular Research

IS - 6

ER -

Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

Abstract

Keywords

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