TY - JOUR
T1 - Synthesis of polymeric nanocapsules by radical UV-activated interface-emulsion polymerization
AU - Bazzano, Marco
AU - Pisano, Roberto
AU - Brelstaff, Jack
AU - Spillantini, Maria Grazia
AU - Sidoryk-Wegrzynowicz, Marta
AU - Rizza, Giancarlo
AU - Sangermano, Marco
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/10/15
Y1 - 2016/10/15
N2 - A new methodology is reported that allows a better control of the synthesis of polymeric core–shell nanocapsules. These nanocapsules were made of biocompatible polymers, obtained from poly(ethylene glycol)diacrylate and poly(ethylene glycol) methyl ether methacrylate, and were used as carrier for curcumin as therapeutic agent. The impact of manufacturing factors (time of sonication, time of UV irradiation, and type of monomer) was investigated in relation to the average size of nanocapsules, their distribution, shape, composition, stability, and their capability to deliver curcumin. We successfully synthesized core–shell nanocapsules in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture. This wide range of sizes makes the method here proposed very promising for the production of nanocarriers.
AB - A new methodology is reported that allows a better control of the synthesis of polymeric core–shell nanocapsules. These nanocapsules were made of biocompatible polymers, obtained from poly(ethylene glycol)diacrylate and poly(ethylene glycol) methyl ether methacrylate, and were used as carrier for curcumin as therapeutic agent. The impact of manufacturing factors (time of sonication, time of UV irradiation, and type of monomer) was investigated in relation to the average size of nanocapsules, their distribution, shape, composition, stability, and their capability to deliver curcumin. We successfully synthesized core–shell nanocapsules in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture. This wide range of sizes makes the method here proposed very promising for the production of nanocarriers.
KW - core–shell nanocapsule
KW - curcumin
KW - drug-delivery systems
KW - interface-emulsion polymerization
KW - mini-emulsion
U2 - 10.1002/pola.28226
DO - 10.1002/pola.28226
M3 - Article
AN - SCOPUS:84978531942
SN - 0887-624X
VL - 54
SP - 3357
EP - 3369
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
IS - 20
ER -