Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

M. C.D. Clochard; S. Brocchini

Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

M. C.D. Clochard
, S. Brocchini

University College London
Centre for Polymer Therapeutics

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

Original language	English
Pages (from-to)	996-997
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Issue number	1
Publication status	Published - 1 Mar 2000
Externally published	Yes
Event	The San Francisco Meeting - San Francisco, CA, USA Duration: 26 Mar 2000 → 31 Mar 2000

Cite this

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title = "Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis",

abstract = "The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.",

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year = "2000",

month = mar,

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language = "English",

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journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

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T1 - Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

AU - Clochard, M. C.D.

AU - Brocchini, S.

PY - 2000/3/1

Y1 - 2000/3/1

N2 - The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

AB - The synthesis of water-soluble polymers derived form cis-aconitic acid and polyethylene glycols (PEG) is described. Polymeric units that maintained a free carboxylic acid cis to an amide bond in the polymer mainchain degraded by a hydrolytic mechanism at pH 5.5 lysosome and 2.0 gut. In vitro biocompatibility assays indicated this polymer to be biocompatible. However, decarboxylation reactions during the synthesis were identified as the probable cause for the generation of nondegradable elements in the polymer mainchain.

M3 - Conference article

AN - SCOPUS:0033750875

SN - 0032-3934

VL - 41

SP - 996

EP - 997

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 1

T2 - The San Francisco Meeting

Y2 - 26 March 2000 through 31 March 2000

ER -

Synthesis of soluble polymers designed to degrade by intramolecular acid catalysis

Abstract

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