Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

Marie Claude Du Bois Clochard; Sheila Rankin; Stephen Brocchini

doi:10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

Marie Claude Du Bois Clochard
, Sheila Rankin
, Stephen Brocchini

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

Original language	English
Pages (from-to)	853-859
Number of pages	7
Journal	Macromolecular Rapid Communications
Volume	21
Issue number	12
DOIs	https://doi.org/10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m
Publication status	Published - 18 Aug 2000
Externally published	Yes

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title = "Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis",

abstract = "Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.",

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AU - Clochard, Marie Claude Du Bois

AU - Rankin, Sheila

AU - Brocchini, Stephen

PY - 2000/8/18

Y1 - 2000/8/18

N2 - Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

AB - Aqueous soluble polymers designed to rapidly degrade by an intramolecular assisted acid catalysed mechanism were prepared. Degradation studies at pH 5.5 and 2.0 exhibited a rapid first phase followed by a slower phase and incomplete degradation to macromonomeric species. The fast phase was attributed to repeat units containing a carboxylic acid pendent chain cis to an amide bond in the polymer mainchain and the slow phase by the absence of this free carboxylic acid moiety.

U2 - 10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

DO - 10.1002/1521-3927(20000801)21:12<853::aid-marc853>3.0.co;2-m

M3 - Article

AN - SCOPUS:23044518587

SN - 1022-1336

VL - 21

SP - 853

EP - 859

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

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ER -

Synthesis of soluble polymers for medicine that degrade by intramolecular acid catalysis

Abstract

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