Synthesis of [3H2]-21-diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor

Jérôme Fagart; Franck Sobrio; Andrée Marquet

doi:10.1002/(SICI)1099-1344(199710)39:10<791::AID-JLCR25>3.0.CO;2-X

Synthesis of [³H₂]-21-diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor

Jérôme Fagart
, Franck Sobrio
, Andrée Marquet

Institut Pierre Simon Laplace, CNRS and CEA
Lab. de Chimie Organique Biologique
Centre national de la recherche scientifique

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

[³H₂]-21-Diazoprogesterone ([³H₂]21DP), a potent photoaffinity labelling reagent, has been synthesized in four steps from progesterone. Tritium has been introduced by homogeneous tritiation with Wilkinson's catalyst.

Original language	English
Pages (from-to)	791-795
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/(SICI)1099-1344(199710)39:10<791::AID-JLCR25>3.0.CO;2-X
Publication status	Published - 1 Jan 1997

Keywords

21-Diazoprogesterone
Homogeneous tritiation
Mineralocorticoid receptor
Photoaffinity labelling

Access to Document

10.1002/(SICI)1099-1344(199710)39:10<791::AID-JLCR25>3.0.CO;2-X

Cite this

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title = "Synthesis of [3H2]-21-diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor",

abstract = "[3H2]-21-Diazoprogesterone ([3H2]21DP), a potent photoaffinity labelling reagent, has been synthesized in four steps from progesterone. Tritium has been introduced by homogeneous tritiation with Wilkinson's catalyst.",

keywords = "21-Diazoprogesterone, Homogeneous tritiation, Mineralocorticoid receptor, Photoaffinity labelling",

author = "J{\'e}r{\^o}me Fagart and Franck Sobrio and Andr{\'e}e Marquet",

year = "1997",

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T1 - Synthesis of [3H2]-21-diazoprogesterone as a potent photoaffinity labelling reagent for the mineralocorticoid receptor

AU - Fagart, Jérôme

AU - Sobrio, Franck

AU - Marquet, Andrée

PY - 1997/1/1

Y1 - 1997/1/1

N2 - [3H2]-21-Diazoprogesterone ([3H2]21DP), a potent photoaffinity labelling reagent, has been synthesized in four steps from progesterone. Tritium has been introduced by homogeneous tritiation with Wilkinson's catalyst.

AB - [3H2]-21-Diazoprogesterone ([3H2]21DP), a potent photoaffinity labelling reagent, has been synthesized in four steps from progesterone. Tritium has been introduced by homogeneous tritiation with Wilkinson's catalyst.

KW - 21-Diazoprogesterone

KW - Homogeneous tritiation

KW - Mineralocorticoid receptor

KW - Photoaffinity labelling

U2 - 10.1002/(SICI)1099-1344(199710)39:10<791::AID-JLCR25>3.0.CO;2-X

DO - 10.1002/(SICI)1099-1344(199710)39:10<791::AID-JLCR25>3.0.CO;2-X

M3 - Article

AN - SCOPUS:0030870490

SN - 0362-4803

VL - 39

SP - 791

EP - 795

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

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