Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis

J. Stephen Clark; Frederic Marlin; Bastien Nay; Claire Wilson

doi:10.1021/ol027265y

Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis

J. Stephen Clark, Frederic Marlin, Bastien Nay, Claire Wilson

University of Nottingham

Research output: Contribution to journal › Article › peer-review

Abstract

(Matrix presented) An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp²-sp³ fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	1
DOIs	https://doi.org/10.1021/ol027265y
Publication status	Published - 9 Jan 2003
Externally published	Yes

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10.1021/ol027265y

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title = "Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis",

abstract = "(Matrix presented) An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp2-sp3 fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products.",

author = "Clark, \{J. Stephen\} and Frederic Marlin and Bastien Nay and Claire Wilson",

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doi = "10.1021/ol027265y",

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T1 - Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis

AU - Clark, J. Stephen

AU - Marlin, Frederic

AU - Nay, Bastien

AU - Wilson, Claire

PY - 2003/1/9

Y1 - 2003/1/9

N2 - (Matrix presented) An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp2-sp3 fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products.

AB - (Matrix presented) An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp2-sp3 fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products.

U2 - 10.1021/ol027265y

DO - 10.1021/ol027265y

M3 - Article

C2 - 12509898

AN - SCOPUS:0038813821

SN - 1523-7060

VL - 5

SP - 89

EP - 92

JO - Organic Letters

JF - Organic Letters

IS - 1

ER -

Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis

Abstract

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