Abstract
The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.
| Original language | English |
|---|---|
| Pages (from-to) | 477-479 |
| Number of pages | 3 |
| Journal | Green Chemistry |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jan 2003 |
| Externally published | Yes |