The mechanical opening of DNA and the sequence content

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Separation of the strands of the DNA molecule play a fundamental role in biology. We here review different experimental and theoretical approaches to DNA opening in vitro. We then analyze the relationship between the sequence content and the opening signal. We focus on a theoretical study of the performances of Bayesian inference to predict the sequence of DNA molecules from fixed-force unzipping experiments.

Original languageEnglish
Title of host publicationFROM PHYSICS TO BIOLOGY
Subtitle of host publicationThe Interface between Experiment and Computation: Bifi 2006 II International Congress
Pages50-63
Number of pages14
DOIs
Publication statusPublished - 1 Dec 2006
EventFROM PHYSICS TO BIOLOGY: The Interface between Experiment and Computation - BIFI 2006 II International Congress - Zaragoza, Spain
Duration: 8 Feb 200611 Feb 2006

Publication series

NameAIP Conference Proceedings
Volume851
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceFROM PHYSICS TO BIOLOGY: The Interface between Experiment and Computation - BIFI 2006 II International Congress
Country/TerritorySpain
CityZaragoza
Period8/02/0611/02/06

Keywords

  • Bayesian inferencea
  • DNA sequence
  • Mechanical unzipping

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