The microwave-assisted synthesis of a 2-carboxyphosphole

Steven van Zutphen; Guilhem Mora; Vicente J. Margarit; Xavier F. Le Goff; Duncan Carmichael; Pascal Le Floch

doi:10.1016/j.tetlet.2008.01.075

The microwave-assisted synthesis of a 2-carboxyphosphole

Steven van Zutphen, Guilhem Mora, Vicente J. Margarit, Xavier F. Le Goff, Duncan Carmichael, Pascal Le Floch

Research output: Contribution to journal › Article › peer-review

Abstract

Using a one-pot four-step reaction a readily available phospholide was converted efficiently to a 2-carboxyphosphole. This compound can be used as a building block for the synthesis of phosphole-containing peptides, where the phosphole can serve as a coordination site for late transition metals and may affect the secondary structure of the peptide.

Original language	English
Pages (from-to)	1734-1737
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2008.01.075
Publication status	Published - 10 Mar 2008
Externally published	Yes

Keywords

Microwave-assisted synthesis
P Ligands
Phosphorus heterocycles
Sigmatropic rearrangement

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10.1016/j.tetlet.2008.01.075

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title = "The microwave-assisted synthesis of a 2-carboxyphosphole",

abstract = "Using a one-pot four-step reaction a readily available phospholide was converted efficiently to a 2-carboxyphosphole. This compound can be used as a building block for the synthesis of phosphole-containing peptides, where the phosphole can serve as a coordination site for late transition metals and may affect the secondary structure of the peptide.",

keywords = "Microwave-assisted synthesis, P Ligands, Phosphorus heterocycles, Sigmatropic rearrangement",

author = "\{van Zutphen\}, Steven and Guilhem Mora and Margarit, \{Vicente J.\} and \{Le Goff\}, \{Xavier F.\} and Duncan Carmichael and \{Le Floch\}, Pascal",

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doi = "10.1016/j.tetlet.2008.01.075",

language = "English",

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T1 - The microwave-assisted synthesis of a 2-carboxyphosphole

AU - van Zutphen, Steven

AU - Mora, Guilhem

AU - Margarit, Vicente J.

AU - Le Goff, Xavier F.

AU - Carmichael, Duncan

AU - Le Floch, Pascal

PY - 2008/3/10

Y1 - 2008/3/10

N2 - Using a one-pot four-step reaction a readily available phospholide was converted efficiently to a 2-carboxyphosphole. This compound can be used as a building block for the synthesis of phosphole-containing peptides, where the phosphole can serve as a coordination site for late transition metals and may affect the secondary structure of the peptide.

AB - Using a one-pot four-step reaction a readily available phospholide was converted efficiently to a 2-carboxyphosphole. This compound can be used as a building block for the synthesis of phosphole-containing peptides, where the phosphole can serve as a coordination site for late transition metals and may affect the secondary structure of the peptide.

KW - Microwave-assisted synthesis

KW - P Ligands

KW - Phosphorus heterocycles

KW - Sigmatropic rearrangement

U2 - 10.1016/j.tetlet.2008.01.075

DO - 10.1016/j.tetlet.2008.01.075

M3 - Article

AN - SCOPUS:39149130671

SN - 0040-4039

VL - 49

SP - 1734

EP - 1737

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

The microwave-assisted synthesis of a 2-carboxyphosphole

Abstract

Keywords

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