TY - JOUR
T1 - The Paris-Sud yeast structural genomics pilot-project
T2 - From structure to function
AU - Quevillon-Cheruel, Sophie
AU - Liger, Dominique
AU - Leulliot, Nicolas
AU - Graille, Marc
AU - Poupon, Anne
AU - De La Sierra-Gallay, Inès Li
AU - Zhou, Cong Zhao
AU - Collinet, Bruno
AU - Janin, Joël
AU - Van Tilbeurgh, Herman
PY - 2004/9/1
Y1 - 2004/9/1
N2 - We present here the outlines and results from our yeast structural genomics (YSG) pilot-project. A lab-scale platform for the systematic production and structure determination is presented. In order to validate this approach, 250 non-membrane proteins of unknown structure were targeted. Strategies and final statistics are evaluated. We finally discuss the opportunity of structural genomics programs to contribute to functional biochemical annotation.
AB - We present here the outlines and results from our yeast structural genomics (YSG) pilot-project. A lab-scale platform for the systematic production and structure determination is presented. In order to validate this approach, 250 non-membrane proteins of unknown structure were targeted. Strategies and final statistics are evaluated. We finally discuss the opportunity of structural genomics programs to contribute to functional biochemical annotation.
KW - Crystallization robotics
KW - Crystallography
KW - Expression
KW - Platform
U2 - 10.1016/j.biochi.2004.09.013
DO - 10.1016/j.biochi.2004.09.013
M3 - Article
C2 - 15556271
AN - SCOPUS:8844246397
SN - 0300-9084
VL - 86
SP - 617
EP - 623
JO - Biochimie
JF - Biochimie
IS - 9-10
ER -