Three-component metal-free arylation of isocyanides

  • Unnamatla M.V. Basavanag
  • , Aurélie Dos Santos
  • , Laurent El Kaim
  • , Rocio Gámez-Montaño
  • , Laurence Grimaud

Research output: Contribution to journalArticlepeer-review

Abstract

Mumm's the word: The title reaction can be performed by the addition of isocyanides to benzenediazonium salts in the presence of sodium or potassium carboxylates. The reaction involves nitrilium intermediates which may be trapped by water or carboxylic acids to form amides and imides, respectively, after Mumm rearrangement.

Original languageEnglish
Pages (from-to)7194-7197
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number28
DOIs
Publication statusPublished - 8 Jul 2013
Externally publishedYes

Keywords

  • arylation
  • isocyanides
  • reaction mechanisms
  • rearrangement
  • synthetic methods

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