Three-component Nef-Huisgen access to 1,2,4-triazoles

Laurent El Kaim; Laurence Grimaud; Simon Wagschal

doi:10.1055/s-0028-1216738

Three-component Nef-Huisgen access to 1,2,4-triazoles

Laurent El Kaim
, Laurence Grimaud
, Simon Wagschal

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

We present herein a new three-component triazole synthesis involving a Nef-Huisgen cascade. After the α-addition of acyl chlorides onto isocyanides (Nef reaction), the resulting imidoyl chloride is treated with tetrazoles under suitable activation (ZnCl₂). The resulting adduct is unstable and evolves according to the Huisgen reaction.

Original language	English
Pages (from-to)	1315-1317
Number of pages	3
Journal	Synlett
Issue number	8
DOIs	https://doi.org/10.1055/s-0028-1216738
Publication status	Published - 1 Jan 2009
Externally published	Yes

Keywords

Huisgen
Isocyanide
Nef
Tetrazoles
Triazoles

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10.1055/s-0028-1216738

Cite this

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title = "Three-component Nef-Huisgen access to 1,2,4-triazoles",

abstract = "We present herein a new three-component triazole synthesis involving a Nef-Huisgen cascade. After the α-addition of acyl chlorides onto isocyanides (Nef reaction), the resulting imidoyl chloride is treated with tetrazoles under suitable activation (ZnCl2). The resulting adduct is unstable and evolves according to the Huisgen reaction.",

keywords = "Huisgen, Isocyanide, Nef, Tetrazoles, Triazoles",

author = "\{El Kaim\}, Laurent and Laurence Grimaud and Simon Wagschal",

year = "2009",

month = jan,

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doi = "10.1055/s-0028-1216738",

language = "English",

pages = "1315--1317",

journal = "Synlett",

issn = "0936-5214",

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TY - JOUR

T1 - Three-component Nef-Huisgen access to 1,2,4-triazoles

AU - El Kaim, Laurent

AU - Grimaud, Laurence

AU - Wagschal, Simon

PY - 2009/1/1

Y1 - 2009/1/1

N2 - We present herein a new three-component triazole synthesis involving a Nef-Huisgen cascade. After the α-addition of acyl chlorides onto isocyanides (Nef reaction), the resulting imidoyl chloride is treated with tetrazoles under suitable activation (ZnCl2). The resulting adduct is unstable and evolves according to the Huisgen reaction.

AB - We present herein a new three-component triazole synthesis involving a Nef-Huisgen cascade. After the α-addition of acyl chlorides onto isocyanides (Nef reaction), the resulting imidoyl chloride is treated with tetrazoles under suitable activation (ZnCl2). The resulting adduct is unstable and evolves according to the Huisgen reaction.

KW - Huisgen

KW - Isocyanide

KW - Nef

KW - Tetrazoles

KW - Triazoles

U2 - 10.1055/s-0028-1216738

DO - 10.1055/s-0028-1216738

M3 - Article

AN - SCOPUS:67649408868

SN - 0936-5214

SP - 1315

EP - 1317

JO - Synlett

JF - Synlett

IS - 8

ER -

Three-component Nef-Huisgen access to 1,2,4-triazoles

Abstract

Keywords

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