Time-resolved circular dichroism in carbonmonoxy-myoglobin: The central role of the proximal histidine

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Abstract

A calculation of the circular dichroism (CD) spectra of carbonmonoxy-and deoxy-myoglobin is carried out in relation to a time-resolved CD experiment. This calculation allows us to assign a dominant role to the proximal histidine in the definition of the electronic normal modes and to interpret the transient CD structure observed in a strain of the proximal histidine. This strain builds up in 10 ps and relaxes in 50 ps as the protein evolves towards its deoxy form.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalChirality
Volume18
Issue number4
DOIs
Publication statusPublished - 9 May 2006

Keywords

  • Myoglobin
  • Time-resolved circular dichroism

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