Towards the synthesis of Paulitin: New insights into the enyne-metathesis mechanism

Emeline Vedrenne; Frédérique Royer; Julie Oble; Laurent El Kaïm; Laurence Grimaud

doi:10.1055/s-2005-872261

Towards the synthesis of Paulitin: New insights into the enyne-metathesis mechanism

Emeline Vedrenne
, Frédérique Royer
, Julie Oble
, Laurent El Kaïm
, Laurence Grimaud

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

In our approach towards Paulitin, a sesquiterpene lactone, we have shown that steric hindrance at the propargylic position is of importance to the outcome of enyne metathesis. Moreover, we have uncovered further evidence to confirm that the alkyne-first pathway should be the favored process in enyne metathesis.

Original language	English
Article number	D16705ST
Pages (from-to)	2379-2381
Number of pages	3
Journal	Synlett
Issue number	15
DOIs	https://doi.org/10.1055/s-2005-872261
Publication status	Published - 19 Sept 2005
Externally published	Yes

Keywords

1,3-dienes
Alkyne
Mechanism
Metathesis
Steric hindrance

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10.1055/s-2005-872261

Cite this

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title = "Towards the synthesis of Paulitin: New insights into the enyne-metathesis mechanism",

abstract = "In our approach towards Paulitin, a sesquiterpene lactone, we have shown that steric hindrance at the propargylic position is of importance to the outcome of enyne metathesis. Moreover, we have uncovered further evidence to confirm that the alkyne-first pathway should be the favored process in enyne metathesis.",

keywords = "1,3-dienes, Alkyne, Mechanism, Metathesis, Steric hindrance",

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AU - Vedrenne, Emeline

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AU - Oble, Julie

AU - El Kaïm, Laurent

AU - Grimaud, Laurence

PY - 2005/9/19

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AB - In our approach towards Paulitin, a sesquiterpene lactone, we have shown that steric hindrance at the propargylic position is of importance to the outcome of enyne metathesis. Moreover, we have uncovered further evidence to confirm that the alkyne-first pathway should be the favored process in enyne metathesis.

KW - 1,3-dienes

KW - Alkyne

KW - Mechanism

KW - Metathesis

KW - Steric hindrance

U2 - 10.1055/s-2005-872261

DO - 10.1055/s-2005-872261

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JF - Synlett

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Towards the synthesis of Paulitin: New insights into the enyne-metathesis mechanism

Abstract

Keywords

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