Abstract
Trichloroacylhydrazones react smoothly at room temperature with β-keto esters to form pyrazoles in high yield. A weak base such as sodium carbonate is necessary for the process to start and best yields are obtained in aprotic polar solvents; a possible mechanism involving chlorine transfer is proposed for this reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 353-354 |
| Number of pages | 2 |
| Journal | Synlett |
| Issue number | 3 |
| Publication status | Published - 1 Jan 2000 |
| Externally published | Yes |
Keywords
- Hydrazones
- Keto esters
- Pyrazoles
- Trichloroacyl