Unified, radical-based approach for the synthesis of spiroketals

Michiel De Greet; Samir Z. Zard

doi:10.1021/ol070488+

Unified, radical-based approach for the synthesis of spiroketals

Michiel De Greet, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

Original language	English
Pages (from-to)	1773-1776
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	9
DOIs	https://doi.org/10.1021/ol070488+
Publication status	Published - 26 Apr 2007
Externally published	Yes

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10.1021/ol070488+

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title = "Unified, radical-based approach for the synthesis of spiroketals",

abstract = "Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.",

author = "\{De Greet\}, Michiel and Zard, \{Samir Z.\}",

year = "2007",

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doi = "10.1021/ol070488+",

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journal = "Organic Letters",

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T1 - Unified, radical-based approach for the synthesis of spiroketals

AU - De Greet, Michiel

AU - Zard, Samir Z.

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Y1 - 2007/4/26

N2 - Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

AB - Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

U2 - 10.1021/ol070488+

DO - 10.1021/ol070488+

M3 - Article

C2 - 17391041

AN - SCOPUS:34248356404

SN - 1523-7060

VL - 9

SP - 1773

EP - 1776

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Unified, radical-based approach for the synthesis of spiroketals

Abstract

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