XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

Céline Vallot; Christophe Huret; Yann Lesecque; Alissa Resch; Noufissa Oudrhiri; Annelise Bennaceur-Griscelli; Laurent Duret; Claire Rougeulle

doi:10.1038/ng.2530

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

Céline Vallot
, Christophe Huret
, Yann Lesecque
, Alissa Resch
, Noufissa Oudrhiri
, Annelise Bennaceur-Griscelli
, Laurent Duret
, Claire Rougeulle

École Polytechnique

Laboratoire de Probabilités et Modèles Aléatoires
Centre national de la recherche scientifique
IGFL, Université de Lyon, Université Lyon 1
Univ. of Connecticut Health Center
University Paris-Saclay

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.

Original language	English
Pages (from-to)	239-241
Number of pages	3
Journal	Nature Genetics
Volume	45
Issue number	3
DOIs	https://doi.org/10.1038/ng.2530
Publication status	Published - 1 Mar 2013

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abstract = "X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.",

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AU - Vallot, Céline

AU - Huret, Christophe

AU - Lesecque, Yann

AU - Resch, Alissa

AU - Oudrhiri, Noufissa

AU - Bennaceur-Griscelli, Annelise

AU - Duret, Laurent

AU - Rougeulle, Claire

PY - 2013/3/1

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N2 - X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.

AB - X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.

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JO - Nature Genetics

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XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

Abstract

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