Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang; Ling Qin; Samir Z. Zard

doi:10.1016/j.tet.2018.08.040

Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang, Ling Qin, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

Original language	English
Pages (from-to)	5804-5817
Number of pages	14
Journal	Tetrahedron
Volume	74
Issue number	40
DOIs	https://doi.org/10.1016/j.tet.2018.08.040
Publication status	Published - 4 Oct 2018
Externally published	Yes

Keywords

C-H functionalization of heteroaromatics
Minisci reaction
Pyrazines
Xanthates

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10.1016/j.tet.2018.08.040

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title = "Xanthate-mediated intermolecular alkylation of pyrazines",

abstract = "An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.",

keywords = "C-H functionalization of heteroaromatics, Minisci reaction, Pyrazines, Xanthates",

author = "Qi Huang and Ling Qin and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = oct,

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doi = "10.1016/j.tet.2018.08.040",

language = "English",

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T1 - Xanthate-mediated intermolecular alkylation of pyrazines

AU - Huang, Qi

AU - Qin, Ling

AU - Zard, Samir Z.

PY - 2018/10/4

Y1 - 2018/10/4

N2 - An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

AB - An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

KW - C-H functionalization of heteroaromatics

KW - Minisci reaction

KW - Pyrazines

KW - Xanthates

U2 - 10.1016/j.tet.2018.08.040

DO - 10.1016/j.tet.2018.08.040

M3 - Article

AN - SCOPUS:85053358891

SN - 0040-4020

VL - 74

SP - 5804

EP - 5817

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -

Xanthate-mediated intermolecular alkylation of pyrazines

Abstract

Keywords

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