Our society is undergoing a revolution that will fundamentally redefine our approach to the biological sciences and to medicine. This revolution is enabled by the convergence of an array of technologies and medical and social practices that offer unprecedented opportunities for innovative approaches to medical practice and to life science research. The vision driving the Engineering for Health (E4H) Center of Institut Polytechnique de Paris (IP Paris) is that seizing these opportunities and realizing their full potential requires a highly interdisciplinary approach where quantitative and social scientists collaborate closely with the life science and medical communities.