2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

Pablo Navarro

doi:10.1016/j.stemcr.2018.06.017

2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

Pablo Navarro

École Polytechnique

Résultats de recherche: Contribution à un journal › Bref sondage › Revue par des pairs

5 Citations (Scopus)

Résumé

In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures.

langue originale	Anglais
Pages (de - à)	1-3
Nombre de pages	3
journal	Stem Cell Reports
Volume	11
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.stemcr.2018.06.017
état	Publié - 10 juil. 2018

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10.1016/j.stemcr.2018.06.017

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title = "2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells",

abstract = "In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures.",

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2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

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