3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

Mehdi Zaghouani; Bastien Nay

doi:10.1039/c5np00144g

3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

Mehdi Zaghouani
, Bastien Nay

CNRS/Museum National d'Histoire Naturelle/IRD/UPMC

Résultats de recherche: Contribution à un journal › Article de révision › Revue par des pairs

Résumé

Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pK_a and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

langue originale	Anglais
Pages (de - à)	540-548
Nombre de pages	9
journal	Natural Product Reports
Volume	33
Numéro de publication	4
Les DOIs	https://doi.org/10.1039/c5np00144g
état	Publié - 1 avr. 2016
Modification externe	Oui

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10.1039/c5np00144g

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abstract = "Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.",

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AB - Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

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3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

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