A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes

Eric Bacqué; François Pautrat; Samir Z. Zard

doi:10.1021/ol027312m

A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes

Eric Bacqué
, François Pautrat
, Samir Z. Zard

Centre de Recherche de Vitry-Alfortville
Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

52 Citations (Scopus)

Résumé

(Matrix presented) A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.

langue originale	Anglais
Pages (de - à)	325-328
Nombre de pages	4
journal	Organic Letters
Volume	5
Numéro de publication	3
Les DOIs	https://doi.org/10.1021/ol027312m
état	Publié - 6 févr. 2003
Modification externe	Oui

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10.1021/ol027312m

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title = "A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes",

abstract = "(Matrix presented) A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.",

author = "Eric Bacqu{\'e} and Fran{\c c}ois Pautrat and Zard, \{Samir Z.\}",

year = "2003",

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T1 - A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes

AU - Bacqué, Eric

AU - Pautrat, François

AU - Zard, Samir Z.

PY - 2003/2/6

Y1 - 2003/2/6

N2 - (Matrix presented) A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.

AB - (Matrix presented) A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.

U2 - 10.1021/ol027312m

DO - 10.1021/ol027312m

M3 - Article

C2 - 12556183

AN - SCOPUS:0038518309

SN - 1523-7060

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EP - 328

JO - Organic Letters

JF - Organic Letters

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ER -

A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes

Résumé

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