A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi Guang Li; Fernando Portela-Cubillo; Samir Z. Zard

doi:10.1021/acs.orglett.6b00656

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi Guang Li
, Fernando Portela-Cubillo
, Samir Z. Zard

Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

24 Citations (Scopus)

Résumé

A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

langue originale	Anglais
Pages (de - à)	1888-1891
Nombre de pages	4
journal	Organic Letters
Volume	18
Numéro de publication	8
Les DOIs	https://doi.org/10.1021/acs.orglett.6b00656
état	Publié - 15 avr. 2016
Modification externe	Oui

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10.1021/acs.orglett.6b00656

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title = "A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids",

abstract = "A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.",

author = "Li, \{Shi Guang\} and Fernando Portela-Cubillo and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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T1 - A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

AU - Li, Shi Guang

AU - Portela-Cubillo, Fernando

AU - Zard, Samir Z.

PY - 2016/4/15

Y1 - 2016/4/15

N2 - A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

AB - A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

U2 - 10.1021/acs.orglett.6b00656

DO - 10.1021/acs.orglett.6b00656

M3 - Article

C2 - 27054488

AN - SCOPUS:84966393386

SN - 1523-7060

VL - 18

SP - 1888

EP - 1891

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

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