A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

Alejandro Cordero-Vargas; Béatrice Quiclet-Sire; Samir Z. Zard

doi:10.1016/j.bmc.2006.05.070

A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

Alejandro Cordero-Vargas
, Béatrice Quiclet-Sire
, Samir Z. Zard

Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

30 Citations (Scopus)

Résumé

A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V₂ receptor antagonist currently in clinical trials.

langue originale	Anglais
Pages (de - à)	6165-6173
Nombre de pages	9
journal	Bioorganic and Medicinal Chemistry
Volume	14
Numéro de publication	18
Les DOIs	https://doi.org/10.1016/j.bmc.2006.05.070
état	Publié - 15 sept. 2006
Modification externe	Oui

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10.1016/j.bmc.2006.05.070

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title = "A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan",

abstract = "A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.",

keywords = "Beckmann rearrangement, Benzazepines, Tolvaptan, Xanthate",

author = "Alejandro Cordero-Vargas and B{\'e}atrice Quiclet-Sire and Zard, \{Samir Z.\}",

year = "2006",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - A flexible approach for the preparation of substituted benzazepines

T2 - Application to the synthesis of tolvaptan

AU - Cordero-Vargas, Alejandro

AU - Quiclet-Sire, Béatrice

AU - Zard, Samir Z.

PY - 2006/9/15

Y1 - 2006/9/15

N2 - A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.

AB - A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.

KW - Beckmann rearrangement

KW - Benzazepines

KW - Tolvaptan

KW - Xanthate

U2 - 10.1016/j.bmc.2006.05.070

DO - 10.1016/j.bmc.2006.05.070

M3 - Article

C2 - 16782344

AN - SCOPUS:33747104133

SN - 0968-0896

VL - 14

SP - 6165

EP - 6173

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 18

ER -

A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

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