A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

Aurore De Rache; Nassima Meriem Gueddouda; Anne Bourdoncle; Paul Hommes; Hans Ulrich Reissig; Jean Louis Mergny

doi:10.1002/chem.201603021

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

Aurore De Rache
, Nassima Meriem Gueddouda
, Anne Bourdoncle
, Paul Hommes
, Hans Ulrich Reissig
, Jean Louis Mergny

INSERM, U869, IECB
Free University of Berlin

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and¹H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

langue originale	Anglais
Pages (de - à)	12651-12654
Nombre de pages	4
journal	Chemistry - A European Journal
Volume	22
Numéro de publication	36
Les DOIs	https://doi.org/10.1002/chem.201603021
état	Publié - 26 août 2016
Modification externe	Oui

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10.1002/chem.201603021

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title = "A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes",

abstract = "G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.",

keywords = "G-quadruplex, G4 ligand, bipyridine, helicase, terpyridine",

author = "\{De Rache\}, Aurore and Gueddouda, \{Nassima Meriem\} and Anne Bourdoncle and Paul Hommes and Reissig, \{Hans Ulrich\} and Mergny, \{Jean Louis\}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

month = aug,

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doi = "10.1002/chem.201603021",

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T1 - A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

AU - De Rache, Aurore

AU - Gueddouda, Nassima Meriem

AU - Bourdoncle, Anne

AU - Hommes, Paul

AU - Reissig, Hans Ulrich

AU - Mergny, Jean Louis

PY - 2016/8/26

Y1 - 2016/8/26

N2 - G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

AB - G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

KW - G-quadruplex

KW - G4 ligand

KW - bipyridine

KW - helicase

KW - terpyridine

U2 - 10.1002/chem.201603021

DO - 10.1002/chem.201603021

M3 - Article

C2 - 27410717

AN - SCOPUS:84983247102

SN - 0947-6539

VL - 22

SP - 12651

EP - 12654

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 36

ER -

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

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