A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones

Alexandre Bruneau; Jean Daniel Brion; Samir Messaoudi; Mouad Alami

doi:10.1039/c4ob01610f

A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones

Alexandre Bruneau
, Jean Daniel Brion
, Samir Messaoudi
, Mouad Alami

Université Paris-Saclay

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)₂/CuI as the catalyst, PPh₃ as the ligand and LiOtBu or KOAc as the base.

langue originale	Anglais
Pages (de - à)	8533-8541
Nombre de pages	9
journal	Organic and Biomolecular Chemistry
Volume	12
Numéro de publication	42
Les DOIs	https://doi.org/10.1039/c4ob01610f
état	Publié - 14 nov. 2014
Modification externe	Oui

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10.1039/c4ob01610f

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title = "A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones",

abstract = "3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.",

author = "Alexandre Bruneau and Brion, \{Jean Daniel\} and Samir Messaoudi and Mouad Alami",

note = "Publisher Copyright: {\textcopyright} the Partner Organisations 2014.",

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month = nov,

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doi = "10.1039/c4ob01610f",

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T1 - A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones

AU - Bruneau, Alexandre

AU - Brion, Jean Daniel

AU - Messaoudi, Samir

AU - Alami, Mouad

N1 - Publisher Copyright: © the Partner Organisations 2014.

PY - 2014/11/14

Y1 - 2014/11/14

N2 - 3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.

AB - 3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.

UR - https://www.scopus.com/pages/publications/84907964910

U2 - 10.1039/c4ob01610f

DO - 10.1039/c4ob01610f

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AN - SCOPUS:84907964910

SN - 1477-0520

VL - 12

SP - 8533

EP - 8541

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 42

ER -

A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones

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