A new MAFia in cancer

Alain Eychène; Nathalie Rocques; Celio Pouponnot

doi:10.1038/nrc2460

A new MAFia in cancer

Alain Eychène
, Nathalie Rocques
, Celio Pouponnot

Résultats de recherche: Contribution à un journal › Article de révision › Revue par des pairs

Résumé

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

langue originale	Anglais
Pages (de - à)	683-693
Nombre de pages	11
journal	Nature Reviews Cancer
Volume	8
Numéro de publication	9
Les DOIs	https://doi.org/10.1038/nrc2460
état	Publié - 1 sept. 2008

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10.1038/nrc2460

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title = "A new MAFia in cancer",

abstract = "Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.",

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AU - Eychène, Alain

AU - Rocques, Nathalie

AU - Pouponnot, Celio

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N2 - Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

AB - Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

U2 - 10.1038/nrc2460

DO - 10.1038/nrc2460

M3 - Review article

C2 - 19143053

AN - SCOPUS:50249164838

SN - 1474-175X

VL - 8

SP - 683

EP - 693

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

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ER -

A new MAFia in cancer

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