A stereoselective synthesis of (+)-L-733,060 from ethyl (R)-(+)-2,3-epoxypropanoate

Sébastien Prévost; Phannarath Phansavath; Mansour Haddad

doi:10.1016/j.tetasy.2009.12.010

A stereoselective synthesis of (+)-L-733,060 from ethyl (R)-(+)-2,3-epoxypropanoate

Sébastien Prévost
, Phannarath Phansavath
, Mansour Haddad

PSL University

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

An asymmetric synthesis of neurokinin substance P receptor antagonist (+)-L-733,060 starting from enantiomerically pure ethyl (R)-(+)-2,3-epoxypropanoate (ethyl glycidate) is described. The synthesis relies on a diastereoselective reductive amination, regioselective intramolecular epoxide opening, and in situ cyclization as the key steps.

langue originale	Anglais
Pages (de - à)	16-20
Nombre de pages	5
journal	Tetrahedron Asymmetry
Volume	21
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.tetasy.2009.12.010
état	Publié - 29 janv. 2010
Modification externe	Oui

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10.1016/j.tetasy.2009.12.010

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title = "A stereoselective synthesis of (+)-L-733,060 from ethyl (R)-(+)-2,3-epoxypropanoate",

abstract = "An asymmetric synthesis of neurokinin substance P receptor antagonist (+)-L-733,060 starting from enantiomerically pure ethyl (R)-(+)-2,3-epoxypropanoate (ethyl glycidate) is described. The synthesis relies on a diastereoselective reductive amination, regioselective intramolecular epoxide opening, and in situ cyclization as the key steps.",

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AU - Haddad, Mansour

PY - 2010/1/29

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N2 - An asymmetric synthesis of neurokinin substance P receptor antagonist (+)-L-733,060 starting from enantiomerically pure ethyl (R)-(+)-2,3-epoxypropanoate (ethyl glycidate) is described. The synthesis relies on a diastereoselective reductive amination, regioselective intramolecular epoxide opening, and in situ cyclization as the key steps.

AB - An asymmetric synthesis of neurokinin substance P receptor antagonist (+)-L-733,060 starting from enantiomerically pure ethyl (R)-(+)-2,3-epoxypropanoate (ethyl glycidate) is described. The synthesis relies on a diastereoselective reductive amination, regioselective intramolecular epoxide opening, and in situ cyclization as the key steps.

UR - https://www.scopus.com/pages/publications/76049112828

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A stereoselective synthesis of (+)-L-733,060 from ethyl (R)-(+)-2,3-epoxypropanoate

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