A versatile radical based approach to O-alkylated hydroxylamines and oximes

Béatrice Quiclet-Sire; Daniel Woollaston; Samir Z. Zard

doi:10.1016/j.tet.2008.08.113

A versatile radical based approach to O-alkylated hydroxylamines and oximes

Béatrice Quiclet-Sire
, Daniel Woollaston
, Samir Z. Zard

Laboratoire de Synthèse Organique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

6 Citations (Scopus)

Résumé

O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.

langue originale	Anglais
Pages (de - à)	11917-11924
Nombre de pages	8
journal	Tetrahedron
Volume	64
Numéro de publication	52
Les DOIs	https://doi.org/10.1016/j.tet.2008.08.113
état	Publié - 22 déc. 2008
Modification externe	Oui

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10.1016/j.tet.2008.08.113

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@article{3a77a1bf30a04b1d8b1c72da10e1bf80,

title = "A versatile radical based approach to O-alkylated hydroxylamines and oximes",

abstract = "O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.",

author = "B{\'e}atrice Quiclet-Sire and Daniel Woollaston and Zard, \{Samir Z.\}",

year = "2008",

month = dec,

day = "22",

doi = "10.1016/j.tet.2008.08.113",

language = "English",

volume = "64",

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journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - A versatile radical based approach to O-alkylated hydroxylamines and oximes

AU - Quiclet-Sire, Béatrice

AU - Woollaston, Daniel

AU - Zard, Samir Z.

PY - 2008/12/22

Y1 - 2008/12/22

N2 - O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.

AB - O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.

U2 - 10.1016/j.tet.2008.08.113

DO - 10.1016/j.tet.2008.08.113

M3 - Article

AN - SCOPUS:56249143056

SN - 0040-4020

VL - 64

SP - 11917

EP - 11924

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -

A versatile radical based approach to O-alkylated hydroxylamines and oximes

Résumé

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