Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

Benoit Schneider; Philippe Meyer; Simon Sarfati; Laurence Mulard; Catherine Guerreiro; Joëlle Boretto; Joël Janin; Michel Véron; Dominique Deville-Bonne; Bruno Canard

doi:10.1081/NCN-100002300

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

Benoit Schneider
, Philippe Meyer
, Simon Sarfati
, Laurence Mulard
, Catherine Guerreiro
, Joëlle Boretto
, Joël Janin
, Michel Véron
, Dominique Deville-Bonne
, Bruno Canard

Institut Pasteur, Paris
CNRS-UPR U. Propre de Recherche 9063
Ecole Superieure Ingenieurs Luminy

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH^-₃) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

langue originale	Anglais
Pages (de - à)	297-306
Nombre de pages	10
journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	20
Numéro de publication	4-7
Les DOIs	https://doi.org/10.1081/NCN-100002300
état	Publié - 1 janv. 2001
Modification externe	Oui

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10.1081/NCN-100002300

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Schneider, B., Meyer, P., Sarfati, S., Mulard, L., Guerreiro, C., Boretto, J., Janin, J., Véron, M., Deville-Bonne, D., & Canard, B. (2001). Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution. Nucleosides, Nucleotides and Nucleic Acids, 20(4-7), 297-306. https://doi.org/10.1081/NCN-100002300

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title = "Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution",

abstract = "Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.",

author = "Benoit Schneider and Philippe Meyer and Simon Sarfati and Laurence Mulard and Catherine Guerreiro and Jo{\"e}lle Boretto and Jo{\"e}l Janin and Michel V{\'e}ron and Dominique Deville-Bonne and Bruno Canard",

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doi = "10.1081/NCN-100002300",

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Schneider, B, Meyer, P, Sarfati, S, Mulard, L, Guerreiro, C, Boretto, J, Janin, J, Véron, M, Deville-Bonne, D & Canard, B 2001, 'Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution', Nucleosides, Nucleotides and Nucleic Acids, VOL. 20, Numéro 4-7, p. 297-306. https://doi.org/10.1081/NCN-100002300

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution. / Schneider, Benoit; Meyer, Philippe; Sarfati, Simon et al.
Dans: Nucleosides, Nucleotides and Nucleic Acids, Vol 20, Numéro 4-7, 01.01.2001, p. 297-306.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase

T2 - Improvement by α-boranophosphate substitution

AU - Schneider, Benoit

AU - Meyer, Philippe

AU - Sarfati, Simon

AU - Mulard, Laurence

AU - Guerreiro, Catherine

AU - Boretto, Joëlle

AU - Janin, Joël

AU - Véron, Michel

AU - Deville-Bonne, Dominique

AU - Canard, Bruno

PY - 2001/1/1

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N2 - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

AB - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

U2 - 10.1081/NCN-100002300

DO - 10.1081/NCN-100002300

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SN - 1525-7770

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IS - 4-7

ER -

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

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