Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Jennifer Beauvarlet; Jean Louis Mergny; Mojgan Djavaheri-Mergny

doi:10.1080/23723556.2019.1604047

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Jennifer Beauvarlet
, Jean Louis Mergny
, Mojgan Djavaheri-Mergny

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

langue originale	Anglais
Numéro d'article	1604047
journal	Molecular and Cellular Oncology
Volume	6
Numéro de publication	4
Les DOIs	https://doi.org/10.1080/23723556.2019.1604047
état	Publié - 4 juil. 2019
Modification externe	Oui

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title = "Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis",

abstract = "G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.",

keywords = "Cancer therapy, DNA damage response, G-quadruplex, autophagy, senescence",

author = "Jennifer Beauvarlet and Mergny, \{Jean Louis\} and Mojgan Djavaheri-Mergny",

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AU - Beauvarlet, Jennifer

AU - Mergny, Jean Louis

AU - Djavaheri-Mergny, Mojgan

PY - 2019/7/4

Y1 - 2019/7/4

N2 - G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

AB - G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

KW - Cancer therapy

KW - DNA damage response

KW - G-quadruplex

KW - autophagy

KW - senescence

UR - https://www.scopus.com/pages/publications/85065536730

U2 - 10.1080/23723556.2019.1604047

DO - 10.1080/23723556.2019.1604047

M3 - Article

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

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M1 - 1604047

ER -

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

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