TY - JOUR
T1 - An in-silico approach to meniscus tissue regeneration
T2 - Modeling, numerical simulation, and experimental analysis
AU - Surulescu, Christina
AU - Grosjean, Elise
AU - Dauner, Martin
AU - Doser, Michael
AU - Jäger, Henry
AU - Keilmann, Alex
AU - Linti, Carsten
AU - Mohanan, Shimi Chettiparambil
AU - Quelhas Teixeira, Graciosa
AU - Redenbach, Claudia
AU - de Roy, Luisa
AU - Seitz, Andreas Martin
AU - Simeon, Bernd
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2026/3/1
Y1 - 2026/3/1
N2 - We develop a model for the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from the dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics.
AB - We develop a model for the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from the dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics.
KW - Dynamics of mesenchymal stem cells and chondrocytes
KW - Interdisciplinary approach
KW - Multiscale mathematical modeling
KW - Numerical simulations
KW - Statistical assessment of CT images
KW - Tissue regeneration
UR - https://www.scopus.com/pages/publications/105020927293
U2 - 10.1016/j.apm.2025.116535
DO - 10.1016/j.apm.2025.116535
M3 - Article
AN - SCOPUS:105020927293
SN - 0307-904X
VL - 151
JO - Applied Mathematical Modelling
JF - Applied Mathematical Modelling
M1 - 116535
ER -