Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

Yi Zang; Grégory Genta-Jouve; Alexandre E. Escargueil; Annette K. Larsen; Laura Guedon; Bastien Nay; Soizic Prado

doi:10.1021/acs.jnatprod.6b00458

Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

Yi Zang
, Grégory Genta-Jouve
, Alexandre E. Escargueil
, Annette K. Larsen
, Laura Guedon
, Bastien Nay
, Soizic Prado

Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245)
Sorbonne Université
Université Paris Descartes

Résultats de recherche: Contribution à un journal › Article de révision › Revue par des pairs

45 Citations (Scopus)

Résumé

New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.

langue originale	Anglais
Pages (de - à)	2991-2996
Nombre de pages	6
journal	Journal of Natural Products
Volume	79
Numéro de publication	12
Les DOIs	https://doi.org/10.1021/acs.jnatprod.6b00458
état	Publié - 23 déc. 2016

Accès au document

10.1021/acs.jnatprod.6b00458

Contient cette citation

@article{521f19c741ab4ae4b89baf9f32e9964b,

title = "Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus",

abstract = "New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.",

author = "Yi Zang and Gr{\'e}gory Genta-Jouve and Escargueil, \{Alexandre E.\} and Larsen, \{Annette K.\} and Laura Guedon and Bastien Nay and Soizic Prado",

note = "Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy.",

year = "2016",

month = dec,

day = "23",

doi = "10.1021/acs.jnatprod.6b00458",

language = "English",

volume = "79",

pages = "2991--2996",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

AU - Zang, Yi

AU - Genta-Jouve, Grégory

AU - Escargueil, Alexandre E.

AU - Larsen, Annette K.

AU - Guedon, Laura

AU - Nay, Bastien

AU - Prado, Soizic

PY - 2016/12/23

Y1 - 2016/12/23

N2 - New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.

AB - New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.

U2 - 10.1021/acs.jnatprod.6b00458

DO - 10.1021/acs.jnatprod.6b00458

M3 - Review article

C2 - 27966935

AN - SCOPUS:85007475032

SN - 0163-3864

VL - 79

SP - 2991

EP - 2996

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 12

ER -

Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

Résumé

Accès au document

Empreinte digitale

Contient cette citation