Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran

Erwan Le Gall; Corinne Gosmini; Michel Troupel

doi:10.1016/j.tetlet.2005.11.070

Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran

Erwan Le Gall
, Corinne Gosmini
, Michel Troupel

Institut de Chimie et des Matériaux de Paris Est, CNRS UPEC/UMR 7182

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

17 Citations (Scopus)

Résumé

The arylation at the α-position of piperidine derivatives is achieved in good yield using aromatic organozinc reagents and either 2-methoxylated or α-cyanated piperidine. Oxygen-containing heterocycles such as 2-methoxy-tetrahydropyran reacts in a same manner to yield efficiently 2-arylated tetrahydropyran.

langue originale	Anglais
Pages (de - à)	455-458
Nombre de pages	4
journal	Tetrahedron Letters
Volume	47
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.tetlet.2005.11.070
état	Publié - 23 janv. 2006
Modification externe	Oui

Accès au document

10.1016/j.tetlet.2005.11.070

Contient cette citation

@article{97f91610b3ef44ffbbb89171e5a6c099,

title = "Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran",

abstract = "The arylation at the α-position of piperidine derivatives is achieved in good yield using aromatic organozinc reagents and either 2-methoxylated or α-cyanated piperidine. Oxygen-containing heterocycles such as 2-methoxy-tetrahydropyran reacts in a same manner to yield efficiently 2-arylated tetrahydropyran.",

keywords = "Acetal, Arylation, Organozinc reagent, α-Aminoether, α-Aminonitrile",

author = "\{Le Gall\}, Erwan and Corinne Gosmini and Michel Troupel",

year = "2006",

month = jan,

day = "23",

doi = "10.1016/j.tetlet.2005.11.070",

language = "English",

volume = "47",

pages = "455--458",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran

AU - Le Gall, Erwan

AU - Gosmini, Corinne

AU - Troupel, Michel

PY - 2006/1/23

Y1 - 2006/1/23

N2 - The arylation at the α-position of piperidine derivatives is achieved in good yield using aromatic organozinc reagents and either 2-methoxylated or α-cyanated piperidine. Oxygen-containing heterocycles such as 2-methoxy-tetrahydropyran reacts in a same manner to yield efficiently 2-arylated tetrahydropyran.

AB - The arylation at the α-position of piperidine derivatives is achieved in good yield using aromatic organozinc reagents and either 2-methoxylated or α-cyanated piperidine. Oxygen-containing heterocycles such as 2-methoxy-tetrahydropyran reacts in a same manner to yield efficiently 2-arylated tetrahydropyran.

KW - Acetal

KW - Arylation

KW - Organozinc reagent

KW - α-Aminoether

KW - α-Aminonitrile

U2 - 10.1016/j.tetlet.2005.11.070

DO - 10.1016/j.tetlet.2005.11.070

M3 - Article

AN - SCOPUS:29144454537

SN - 0040-4039

VL - 47

SP - 455

EP - 458

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Aromatic organozinc reagents as nucleophiles in the α-arylation of piperidine and tetrahydropyran

Résumé

Accès au document

Empreinte digitale

Contient cette citation