TY - GEN
T1 - Biochemical Threshold Function Implementation with Zero-Order Ultrasensitivity
AU - Huang, Wei Chih
AU - Jiang, Jie Hong Roland
AU - Fages, Francois
AU - Molina, Franck
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Engineering biochemical reactions is a key task in synthetic biology to enable biomedical and other applications. The biochemical threshold function is a crucial component in the biosensor circuits to be deployed in living cells or synthetic vesicles for disease diagnosis. In this work, based on the zero-order ultrasensitivity, we propose an economic biochemical implementation of threshold functions with reconfigurable threshold values. We show that the so-constructed threshold function module well approximates the unit step function and allows robust composition with other function modules for complex computation tasks.
AB - Engineering biochemical reactions is a key task in synthetic biology to enable biomedical and other applications. The biochemical threshold function is a crucial component in the biosensor circuits to be deployed in living cells or synthetic vesicles for disease diagnosis. In this work, based on the zero-order ultrasensitivity, we propose an economic biochemical implementation of threshold functions with reconfigurable threshold values. We show that the so-constructed threshold function module well approximates the unit step function and allows robust composition with other function modules for complex computation tasks.
U2 - 10.1109/BIOCAS.2019.8919176
DO - 10.1109/BIOCAS.2019.8919176
M3 - Conference contribution
AN - SCOPUS:85077028195
T3 - BioCAS 2019 - Biomedical Circuits and Systems Conference, Proceedings
BT - BioCAS 2019 - Biomedical Circuits and Systems Conference, Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2019 IEEE Biomedical Circuits and Systems Conference, BioCAS 2019
Y2 - 17 October 2019 through 19 October 2019
ER -