Cobalt-Catalyzed Reductive Cross-Coupling To Construct Csp3-Csp3 Bonds via Csp3-S and Csp3-X Bonds Activation

Meng Yu Gao; Corinne Gosmini

doi:10.1021/acs.orglett.3c02993

Cobalt-Catalyzed Reductive Cross-Coupling To Construct Csp³-Csp³ Bonds via Csp³-S and Csp³-X Bonds Activation

Meng Yu Gao
, Corinne Gosmini

CNRS

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

A cross-electrophilic coupling of benzyl sulfonium salts with alkyl halides forming Csp³-Csp³ bonds is described by using a Co-based catalytic system. The activation of the stable Csp³-S bond of benzyl sulfonium salts under mild reaction conditions leads to various functionalized alkyl derivatives. Preliminary mechanistic studies suggest the involvement of alkyl radicals formed from both alkyl halides and benzyl sulfoniums through a single electron transfer.

langue originale	Anglais
Pages (de - à)	7689-7693
Nombre de pages	5
journal	Organic Letters
Volume	25
Numéro de publication	42
Les DOIs	https://doi.org/10.1021/acs.orglett.3c02993
état	Publié - 27 oct. 2023
Modification externe	Oui

Accès au document

10.1021/acs.orglett.3c02993

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Contient cette citation

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title = "Cobalt-Catalyzed Reductive Cross-Coupling To Construct Csp3-Csp3 Bonds via Csp3-S and Csp3-X Bonds Activation",

abstract = "A cross-electrophilic coupling of benzyl sulfonium salts with alkyl halides forming Csp3-Csp3 bonds is described by using a Co-based catalytic system. The activation of the stable Csp3-S bond of benzyl sulfonium salts under mild reaction conditions leads to various functionalized alkyl derivatives. Preliminary mechanistic studies suggest the involvement of alkyl radicals formed from both alkyl halides and benzyl sulfoniums through a single electron transfer.",

author = "Gao, \{Meng Yu\} and Corinne Gosmini",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society",

year = "2023",

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doi = "10.1021/acs.orglett.3c02993",

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AU - Gosmini, Corinne

PY - 2023/10/27

Y1 - 2023/10/27

N2 - A cross-electrophilic coupling of benzyl sulfonium salts with alkyl halides forming Csp3-Csp3 bonds is described by using a Co-based catalytic system. The activation of the stable Csp3-S bond of benzyl sulfonium salts under mild reaction conditions leads to various functionalized alkyl derivatives. Preliminary mechanistic studies suggest the involvement of alkyl radicals formed from both alkyl halides and benzyl sulfoniums through a single electron transfer.

AB - A cross-electrophilic coupling of benzyl sulfonium salts with alkyl halides forming Csp3-Csp3 bonds is described by using a Co-based catalytic system. The activation of the stable Csp3-S bond of benzyl sulfonium salts under mild reaction conditions leads to various functionalized alkyl derivatives. Preliminary mechanistic studies suggest the involvement of alkyl radicals formed from both alkyl halides and benzyl sulfoniums through a single electron transfer.

UR - https://www.scopus.com/pages/publications/85175356001

U2 - 10.1021/acs.orglett.3c02993

DO - 10.1021/acs.orglett.3c02993

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AN - SCOPUS:85175356001

SN - 1523-7060

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JO - Organic Letters

JF - Organic Letters

IS - 42