Comparison between α- And β-carbonic anhydrases: Can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

Florent Pannetier; Gilles Ohanessian; Gilles Frison

doi:10.1039/c0dt01454k

Comparison between α- And β-carbonic anhydrases: Can Zn(His)₃(H₂O) and Zn(His)(Cys)₂(H₂O) sites lead to equivalent enzymes?

Florent Pannetier
, Gilles Ohanessian
, Gilles Frison

CNRS

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

7 Citations (Scopus)

Résumé

Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.

langue originale	Anglais
Pages (de - à)	2696-2698
Nombre de pages	3
journal	Dalton Transactions
Volume	40
Numéro de publication	12
Les DOIs	https://doi.org/10.1039/c0dt01454k
état	Publié - 28 mars 2011
Modification externe	Oui

Accès au document

10.1039/c0dt01454k

Contient cette citation

@article{c234786f9cea415ab3fc88e58726736a,

title = "Comparison between α- And β-carbonic anhydrases: Can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?",

abstract = "Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.",

author = "Florent Pannetier and Gilles Ohanessian and Gilles Frison",

year = "2011",

month = mar,

day = "28",

doi = "10.1039/c0dt01454k",

language = "English",

volume = "40",

pages = "2696--2698",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - Comparison between α- And β-carbonic anhydrases

T2 - Can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

AU - Pannetier, Florent

AU - Ohanessian, Gilles

AU - Frison, Gilles

PY - 2011/3/28

Y1 - 2011/3/28

N2 - Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.

AB - Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.

U2 - 10.1039/c0dt01454k

DO - 10.1039/c0dt01454k

M3 - Article

C2 - 21298147

AN - SCOPUS:79952664519

SN - 1477-9226

VL - 40

SP - 2696

EP - 2698

JO - Dalton Transactions

JF - Dalton Transactions

IS - 12

ER -

Comparison between α- And β-carbonic anhydrases: Can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

Résumé

Accès au document

Empreinte digitale

Contient cette citation

Comparison between α- And β-carbonic anhydrases: Can Zn(His)₃(H₂O) and Zn(His)(Cys)₂(H₂O) sites lead to equivalent enzymes?