CycSim - An online tool for exploring and experimenting with genome-scale metabolic models

F. Le Fèvre; S. Smidtas; C. Combe; M. Durot; Florence D'Alché-Buc; V. Schachter

doi:10.1093/bioinformatics/btp268

CycSim - An online tool for exploring and experimenting with genome-scale metabolic models

F. Le Fèvre
, S. Smidtas
, C. Combe
, M. Durot
, Florence D'Alché-Buc
, V. Schachter

Genoscope - Centre National de Séquençage
GENOPOLE

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

CycSim is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from BioCyc and KEGG. Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. CycSim also functions as an online repository of genome-scale metabolic models.

langue originale	Anglais
Pages (de - à)	1987-1988
Nombre de pages	2
journal	Bioinformatics
Volume	25
Numéro de publication	15
Les DOIs	https://doi.org/10.1093/bioinformatics/btp268
état	Publié - 1 janv. 2009
Modification externe	Oui

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10.1093/bioinformatics/btp268

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abstract = "CycSim is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from BioCyc and KEGG. Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. CycSim also functions as an online repository of genome-scale metabolic models.",

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AU - Le Fèvre, F.

AU - Smidtas, S.

AU - Combe, C.

AU - Durot, M.

AU - D'Alché-Buc, Florence

AU - Schachter, V.

PY - 2009/1/1

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AB - CycSim is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from BioCyc and KEGG. Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. CycSim also functions as an online repository of genome-scale metabolic models.

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DO - 10.1093/bioinformatics/btp268

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VL - 25

SP - 1987

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JO - Bioinformatics

JF - Bioinformatics

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ER -

CycSim - An online tool for exploring and experimenting with genome-scale metabolic models

Résumé

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